TRAINING RHESUS MACAQUES TO TAKE DAILY ORAL ANTIRETROVIRAL THERAPY FOR PRECLINICAL EVALUATION OF HIV PREVENTION AND TREATMENT STRATEGIES.

Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies.

BackgroundMacaque models of simian or simian/human immunodeficiency virus (SIV or SHIV) infection are critical for the evaluation of antiretroviral (ARV)-based HIV treatment and prevention strategies.However, modelling human oral ARV administration is logistically challenging and fraught by limited adherence.Here, we developed a protocol for admini

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Comparative Effectiveness of Enhanced Patient Instructions for Bowel Preparation Before Colonoscopy: Network Meta-analysis of 23 Randomized Controlled Trials

BackgroundVarious enhanced patient instructions (EPIs) have been used for bowel preparation (BP) and our previous meta-analysis also demonstrated the efficacy of EPIs in increasing the colonic polyp and adenoma detection rates; however, the optimal method for adequate BP has not yet been developed.ObjectiveWe performed a network meta-analysis to de

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The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists

Abstract Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide.As young intensivists, we have been at the forefront of the fight against the COVID-19 pandemic and it has been an intense learning experience affecting all aspects of our specialty.Critical care was put forward as Can Opener a priori

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